Cardiotoxicity of non-cardiovascular drugs

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Omschrijving

Some drugs which are not aimed at treating heart disease havenevertheless been found to have profound effects on heart muscle.Cardiotoxicity is one of the major forms of toxicity seen in drugsand it a...
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Uitgebreide omschrijving

Some drugs which are not aimed at treating heart disease havenevertheless been found to have profound effects on heart muscle.Cardiotoxicity is one of the major forms of toxicity seen in drugsand it accounts for most drug recalls and delays experienced inregulatory approvals.In recent years a number of non-cardiacblockbuster drugs such as terfenadine have been withdrawn frommajor markets because of cardiotoxicity concerns, while other drugshave either been withdrawn prior to marketing or required labellingchanges that significantly restricted their use.

In Cardiotoxicity of Non-Cardiovascular Drugsinternational experts describe the molecular mechanisms andclinical read-outs of cardiac events induced by a broad variety ofnoncardiovascular drugs. Particular emphasis is paid to thepreclinical screening of drug cardiotoxicity.

Uitgever John Wiley & Sons Ltd
Druk 1
ISBN/EAN 9780470772744
Auteur Minotti, G.
Vakken Scheikunde

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