Methods in observational epidemiology

Providing a comprehensive picture of the design, conduct, analysis, and interpretation of non-experimental studies of both infectious and non-infectious diseases, the Second Edition of this widely used text has been thoroughly updated to take into account the numerous developments in epidemiology over the past decade. Since the first edition was published in 1986, additional sources of data have become available through the increasing use of computerized records for health-related purposes. Also, a better understanding of the uses and limitations of certain epidemiologic concepts has been gained. Modifications of traditional study designs, including nested case-control studies and case-cohort studies, are now more frequently employed. Biological markers of exposure, disease susceptibility, and disease itself are used in many studies and methods of statistical analysis have been further developed. All of these developments have been considered in writing the Second Edition. The authors cover the full scope of observational studies, describing in detail cohort studies, case-control studies, cross-sectional studies, and epidemic investigation.